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Published on: June 11, 2011
PREVALENCE AND FACTORS ASSOCIATED WITH BACTERIAL INFECTION IN CIRRHOTIC PATIENTS IN TOGO
Laté Mawuli Lawson-Ananissoh1,2, Mawunyo Henoc Gbolou1, Debehoma Venceslas Redah1
1Hepato Gastroenterology Department, Campus Teaching Hospital, Lome, Togo.
Objectives:
to determine the prevalence and identify the factors associated with bacterial infection in cirrhotic patients in Togo.
Methods:
This was a descriptive and analytical cross-sectional study, with retrospective data collection, conducted in the hepato-gastroenterology department of the Campus University Hospital during three years. All patients hospitalized in the department during this period and diagnosed with cirrhosis were included in the study.
Results:
During the study period, 270 patients were hospitalized for cirrhosis including 63 cases of bacterial infection, a prevalence of 23.3%. Bacterial infections were represented by spontaneous infection of ascites fluid (15.9%) followed by urinary tract infection (4%). The median length of hospital stay was 10 days Thirty-six of the patients with infection died in hospital, corresponding to a mortality rate of 57.1%. Factors associated with bacterial infection were ascites (P=0.017; OR=4.56), hepatic encephalopathy (P=0.02; OR=4.32), a prothrombin level below 25% (P=0.002; OR=9.67) and a high MELD score (P=0.03; OR=0.93).
Conclusion:
Bacterial infection occurs in advanced cirrhosis and is associated with a poor prognosis.
Background:
• Bacterial infections are a frequent complication of cirrhosis and were associated with ascites, hepatic encephalopathy and a high MELD score.
Background:
• The most frequent type of infection in this study was spontaneous bacterial peritonitis followed by urinary tract infection.
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