Related Experiment Video
Updated: Sep 14, 2025
07:32
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
4.4K
The intestine and cardiovascular disease
Samuel C Delk1,2, Srinivasa T Reddy1,2,3, Alan M Fogelman1
1Division of Cardiology, Department of Medicine.
Current Opinion in Lipidology
|July 23, 2025
Summary
The gut microbiome and tryptophan metabolism significantly impact cardiovascular disease risk. Altering the 5-hydroxytryptamine (serotonin) pathway in the intestine can reduce atherosclerosis progression.
Area of Science:
- Gastroenterology
- Cardiology
- Microbiology
Background:
- Cardiovascular disease (CVD) pathogenesis is increasingly linked to intestinal health.
- The gut microbiota and its metabolites play a crucial role in systemic inflammation and metabolic processes.
Purpose of the Study:
- To review recent literature on the intestine's role in CVD.
- To investigate the impact of intestinal tryptophan metabolism and microbiota on atherosclerosis.
Main Methods:
- Analysis of fecal microbiota and lipopolysaccharide (LPS) levels in relation to cardiovascular events.
- Utilizing Ldlr-/- mice fed a high-fat, high-cholesterol diet (HFD+HCD) to model atherosclerosis.
- Investigating the effects of indoleamine-2,3-dioxygenase 1 (IDO1) deficiency and 5-hydroxytryptamine (5-HT) pathway inhibition in mice.
Main Results:
- Fecal microbiota and LPS patterns predicted future cardiovascular events.
- High-fat diets increased intestinal IDO1 activity, reducing beneficial metabolites like butyrate and serotonin.
- IDO1 deficiency or 5-HT pathway inhibition in mice improved gut barrier function, reduced inflammation, and decreased atherosclerosis.
Conclusions:
- Intestinal tryptophan metabolism and microbiota-derived products are critical in atherosclerosis development.
- Targeting the intestinal 5-HT pathway offers a potential therapeutic strategy for CVD.
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