Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions

Allergic Reactions

Factors Affecting Drug Response: Overview

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.

Cross-reactivity

Cross-reactivity

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lateral-Conforming Dual-Pivot Versus Nonconforming Anterior-Stabilized Bearings in Valgus Knees Undergoing Primary Total Knee Arthroplasty.

The Journal of arthroplasty·2026

Same author

Effectiveness and Safety of Dupilumab in Patients with Chronic Rhinosinusitis with Nasal Polyps and Associated T2 Comorbidities: One-Year Real Life Round.

Journal of clinical medicine·2026

Same author

Use of lactic acid bacteria to reduce the IgE-reactivity of the arginine kinase allergen from the edible insect Hermetia illucens.

Food research international (Ottawa, Ont.)·2026

Same author

Connecting the Airways: Current Trends in United Airway Diseases.

Journal of personalized medicine·2026

Same author

Treatment of neck fractures of the fifth metacarpal with MIROS (minimally invasive reduction and osteosynthesis system): a retrospective case-series.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2025

Same author

Edible Insects and Allergenic Potential: An Observational Study About In Vitro IgE-Reactivity to Recombinant Pan-Allergens of the Black Soldier Fly (<i>Hermetia illucens</i>) in Patients Sensitized to Crustaceans and Mites.

International journal of molecular sciences·2025

Search research articles

Related Experiment Video

Updated: Sep 14, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Age-dependent differences in anaphylaxis: elderly population.

Alessandro Barone¹, Francesca Nicoletta², Martina Ottoni¹

¹Allergy and Clinical Immunology, Medicine and Surgery Department, University of Parma, Parma.

Current Opinion in Allergy and Clinical Immunology

|July 23, 2025

Summary

Anaphylaxis in older adults is often triggered by drugs and insect venom. Cardiovascular symptoms like syncope are common, and while adrenaline is key, its use remains suboptimal in this vulnerable population.

Keywords:

adrenaline anaphylaxis elderly population food allergy senescence

More Related Videos

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Related Experiment Videos

Last Updated: Sep 14, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Area of Science:

Gerontology
Immunology
Emergency Medicine

Background:

Anaphylaxis in the elderly is understudied despite population growth.
Age-dependent differences exist in anaphylaxis triggers, cofactors, and symptoms.

Purpose of the Study:

To review elicitors, risk factors, clinical manifestations, and management of anaphylaxis in individuals over 65.
To highlight age-specific considerations for anaphylaxis in the elderly population.

Main Methods:

Literature review focusing on studies of anaphylaxis in individuals aged 65 and older.
Analysis of available data on triggers, symptoms, and treatment outcomes.

Main Results:

Drugs and insect venom are primary anaphylaxis triggers in the elderly.
Idiopathic and food-related anaphylaxis rates are increasing in older adults.
Elderly patients face higher risks due to comorbidities and polypharmacy, leading to poorer outcomes.

Conclusions:

Cardiovascular symptoms, particularly syncope, are characteristic of anaphylaxis in older adults.
Adrenaline is the primary treatment, but its use is suboptimal in this age group.
Effective management requires addressing comorbidities and optimizing adrenaline administration in elderly patients.