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Related Experiment Video

Updated: Sep 14, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

B Cell Dynamics and Transitional B Cells in Long COVID.

Zoia R Korobova^1,2, Natalia A Arsentieva^1,2, Natalia E Liubimova¹

¹Laboratory of Molecular Immunology, Saint Petersburg Pasteur Institute, ul. Mira, 14, 197101 Saint Petersburg, Russia.

Current Issues in Molecular Biology

|July 23, 2025

Summary

Long COVID patients show altered B cell populations, with fewer transitional cells. These B cell changes and elevated IL-5/IL-13 cytokines may contribute to long COVID development and autoimmune issues.

Keywords:

B cells CD27 CD38 Th2 cytokines long COVID transitional B cells

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Last Updated: Sep 14, 2025

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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

Area of Science:

Immunology
Virology
Pathophysiology

Background:

Long COVID presents persistent symptoms post-SARS-CoV-2 infection.
Understanding the immune system's role in long COVID is crucial.

Purpose of the Study:

Evaluate immune markers in long COVID patients.
Assess antigen-specific antibodies, B cell subsets, and Th2 cytokines.
Investigate their impact on long COVID development.

Main Methods:

Analyzed blood plasma from 63 long COVID patients and 47 controls.
Measured IgG antibodies via ELISA.
Assessed B cell subsets (CD27, CD38) by flow cytometry.
Quantified Th2 cytokines (IL-4, IL-5, IL-13) using xMAP.

Main Results:

No significant IgG differences between groups.
Long COVID patients had more naive mature B cells and fewer transitional/double-negative B cells.
Elevated IL-5 and IL-13 levels were found in long COVID patients.
Transitional B cell percentage predicted long COVID status.

Conclusions:

Long COVID is associated with significant alterations in B cell dynamics.
These B cell changes may play a role in long COVID pathogenesis.
Potential contribution to autoimmune processes in long COVID.