Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

2.5K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
2.5K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

13.5K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
13.5K
Rab Proteins01:14

Rab Proteins

4.1K
Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
4.1K
Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

7.7K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
7.7K
Exon Recombination02:32

Exon Recombination

3.7K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.7K
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

2.5K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Granulosa cell glycogen fuels the avascular corpus luteum.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Multidimensional nano-ion composite hydrogel based on enzymatic blood glucose control, gas therapy and ion liquid permeation for repairing diabetic wounds.

Materials today. Bio·2026
Same author

A biohybrid platform integrating bacterial propulsion and photoresponsive nanomedicine for adequate intratumoral drug delivery.

Journal of nanobiotechnology·2026
Same author

VolSegGS: Segmentation and Tracking in Dynamic Volumetric Scenes via Deformable 3D Gaussians.

IEEE transactions on visualization and computer graphics·2025
Same author

AortaDiff: Volume-Guided Conditional Diffusion Models for Multi-Branch Aortic Surface Generation.

IEEE transactions on visualization and computer graphics·2025
Same author

MoE-INR: Implicit Neural Representation with Mixture-of-Experts for Time-Varying Volumetric Data Compression.

IEEE transactions on visualization and computer graphics·2025

Related Experiment Video

Updated: Sep 14, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.3K

FGFRL1: Structure, Molecular Function, and Involvement in Human Disease.

Lina Guan1, Li Feng1, Chaoli Wang1

  • 1Institute of Basic Medicine Sciences and Forensic Medicine, North Sichuan Medical College, Fujiang Road, Nanchong 637000, China.

Current Issues in Molecular Biology
|July 23, 2025
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor receptor-like 1 (FGFRL1) is a multifunctional protein involved in growth and development. FGFRL1 dysfunction is linked to various human diseases, including cancer and osteoporosis.

Keywords:
FGFRL1human diseasemolecular functionstructure

More Related Videos

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
10:16

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

7.4K
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

857

Related Experiment Videos

Last Updated: Sep 14, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.3K
SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
10:16

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

7.4K
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

857

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Fibroblast growth factor receptor-like 1 (FGFRL1) is a recently identified member of the fibroblast growth factor receptor (FGFR) family.
  • Initially considered a decoy receptor due to its lack of intracellular tyrosine kinase activity, FGFRL1 is now recognized for its diverse biological roles.
  • Its extracellular domain mimics conventional FGFRs, but its intracellular portion cannot mediate FGF-dependent signal transduction.

Purpose of the Study:

  • To review the current research progress on FGFRL1.
  • To summarize FGFRL1's subcellular localization, molecular functions, and associated human diseases.
  • To provide resources for further investigation into FGFRL1's mechanisms and related pathologies.

Main Methods:

  • Literature review of existing studies on FGFRL1.
  • Analysis of data on FGFRL1's role in prenatal and postnatal growth, organ development, cellular behavior, and signal transduction.
  • Compilation of information on diseases linked to FGFRL1 abnormalities.

Main Results:

  • FGFRL1 plays a crucial role in cartilage and bone development (osteogenesis) and embryonic development of the kidney and diaphragm.
  • It modulates cellular behaviors and participates in cell signal transduction pathways.
  • Functional abnormalities of FGFRL1 are associated with congenital diseases, hypertension, osteoporosis, neurodegenerative disorders, and various cancers.

Conclusions:

  • FGFRL1 is a multifunctional protein with significant implications beyond its initial classification as a decoy receptor.
  • Understanding FGFRL1's diverse roles is critical for elucidating the mechanisms underlying numerous human diseases.
  • Further research into FGFRL1 holds potential for developing novel therapeutic strategies for related conditions.