Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

7.9K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of topical and oral combination of ethanolic extract of <i>Graptophyllum pictum</i> leaf on the inflammation level of rectoanal tissue in hemorrhoid-induced rat.

Open veterinary journal·2026
Same author

The influence of CD117, CD133, CD24, CD44, and ALDH expression on progression-free survival in advanced-stage epithelial ovarian cancer patients.

Cancer treatment and research communications·2026
Same author

Computational and Cytotoxicity Evaluation of Phyllanthus Urinaria-Derived Compounds as Potential Anti-Cervical Cancer Agents via HPV-16 E6 Oncoprotein Inhibition.

International journal of molecular sciences·2026
Same author

Mechanism of FoxO1 in the Metabolic Shift of Fetal Rat Heart.

Molecules (Basel, Switzerland)·2026
Same author

Temporal Trends in Vulvar Cancer Cases and Associated Factors of Adverse Clinical Features: A 6-year Retrospective Study From a Tertiary Hospital in Indonesia.

International journal of women's health·2026
Same author

Expression of miR-92a and miR-125b and Their Association with Chemoradiotherapy Response in Locally Advanced Cervical Cancer.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Sep 14, 2025

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

7.7K

Investigating LATS1 and NF-κB as Predictors of Radiotherapy Response in Cervical Cancer.

Andi Darma Putra1,2,3, Andrijono2, Hariyono Winarto2

  • 1Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Central Jakarta 10430, Indonesia.

Current Issues in Molecular Biology
|July 23, 2025
PubMed
Summary

High Large Tumor Suppressor Kinase-1 (LATS1) levels indicate radioresistance in cervical cancer patients. Lower Nuclear Factor Kappa-B (NF-κB) expression also suggests unresponsiveness to radiation therapy, offering potential biomarkers.

Keywords:
LATS1NF-κBbiomarkercervical cancerradioresistanceradiotherapy

More Related Videos

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.6K
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

696

Related Experiment Videos

Last Updated: Sep 14, 2025

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

7.7K
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.6K
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

696

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • Cervical cancer is a leading global cancer in women.
  • Large Tumor Suppressor Kinase-1 (LATS1) and Nuclear Factor Kappa-B (NF-κB) are potential biomarkers for radioresistance.
  • Understanding radioresistance is crucial for optimizing cervical cancer treatment.

Purpose of the Study:

  • To evaluate LATS1 and NF-κB as biomarkers for radioresistance in cervical cancer.
  • To assess the response of LATS1 and NF-κB levels to radiation therapy.
  • To investigate the correlation between protein expression and treatment outcomes.

Main Methods:

  • Cross-sectional study of 114 advanced-stage cervical cancer patients (IIIB and IVA).
  • ELISA measurement of LATS1 and NF-κB concentrations from pre-radiotherapy biopsy samples.
  • Analysis of protein expression cut-offs and correlation with radiation response.

Main Results:

  • Higher LATS1 expression correlated with unresponsiveness to radiotherapy (p ≤ 0.001).
  • Lower NF-κB expression was associated with radioresistance (p = 0.009).
  • Elevated LATS1 suggests inverse prediction of radioresistance; NF-κB shows a weak correlation.

Conclusions:

  • LATS1 may serve as a significant biomarker for predicting radioresistance in cervical cancer.
  • NF-κB expression has a limited association with radiation resistance.
  • Further research is warranted to validate these findings for clinical application.