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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

33
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

49
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
49
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

31
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
31
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

42
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
42
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

213
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
213

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Uncovering Proteins Commonly Expressed Between Heart Failure and Dementia Using Bioinformatic Tools.

Filipa J Costa1, Rui Vitorino1,2,3, Fernando Ribeiro4

  • 1Institute of Biomedicine (iBiMED), Department of Medical Science, University of Aveiro, 3810-193 Aveiro, Portugal.

Current Issues in Molecular Biology
|July 23, 2025
PubMed
Summary
This summary is machine-generated.

Heart failure and dementia share common risk factors in older adults. This study identifies key proteins like APOE and ACE involved in the heart-brain axis, offering potential biomarkers for these conditions.

Keywords:
DisGeNETSTRINGVOSviewerbioinformaticsg:Profilerheart–brain axis

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Area of Science:

  • Gerontology
  • Neuroscience
  • Cardiology

Background:

  • Heart failure (HF) and dementia are prevalent in the elderly, with HF patients facing increased cognitive decline risk.
  • Cognitive impairment is a shared comorbidity, yet underlying mechanisms linking HF and dementia remain unclear.

Purpose of the Study:

  • To identify proteins that potentially modulate the relationship between heart failure and dementia.
  • To investigate molecular players in the heart-brain axis relevant to aging-related cognitive and cardiovascular diseases.

Main Methods:

  • Utilized a bioinformatic pipeline for comprehensive literature searching.
  • Applied computational tools to analyze and synthesize existing research data.

Main Results:

  • Identified apolipoprotein E (APOE), c-reactive protein (CRP), interleukin 6 (IL6), renin (REN), and angiotensin-converting enzyme (ACE) as key proteins.
  • These proteins are crucial for heart-brain axis homeostasis; their dysregulation is linked to neuronal and cardiovascular diseases.

Conclusions:

  • Highlighted specific proteins that may elucidate the pathophysiology linking heart failure and dementia.
  • These identified proteins represent potential biomarkers and therapeutic targets for co-occurring cardiovascular and neurological conditions.