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Uncovering Proteins Commonly Expressed Between Heart Failure and Dementia Using Bioinformatic Tools

Filipa J Costa1, Rui Vitorino1,2,3, Fernando Ribeiro4

  • 1Institute of Biomedicine (iBiMED), Department of Medical Science, University of Aveiro, 3810-193 Aveiro, Portugal.

Current Issues in Molecular Biology
|July 23, 2025
PubMed

Insights

Heart failure and dementia share common risk factors in older adults. This study identifies key proteins like APOE and ACE involved in the heart-brain axis, offering potential biomarkers for these conditions.

Area of Science:

  • Gerontology
  • Neuroscience
  • Cardiology

Background:

  • Heart failure (HF) and dementia are prevalent in the elderly, with HF patients facing increased cognitive decline risk.
  • Cognitive impairment is a shared comorbidity, yet underlying mechanisms linking HF and dementia remain unclear.

Purpose of the Study:

  • To identify proteins that potentially modulate the relationship between heart failure and dementia.
  • To investigate molecular players in the heart-brain axis relevant to aging-related cognitive and cardiovascular diseases.

Main Methods:

  • Utilized a bioinformatic pipeline for comprehensive literature searching.
  • Applied computational tools to analyze and synthesize existing research data.

Main Results:

  • Identified apolipoprotein E (APOE), c-reactive protein (CRP), interleukin 6 (IL6), renin (REN), and angiotensin-converting enzyme (ACE) as key proteins.
  • These proteins are crucial for heart-brain axis homeostasis; their dysregulation is linked to neuronal and cardiovascular diseases.

Conclusions:

  • Highlighted specific proteins that may elucidate the pathophysiology linking heart failure and dementia.
  • These identified proteins represent potential biomarkers and therapeutic targets for co-occurring cardiovascular and neurological conditions.

Keywords:
DisGeNETSTRINGVOSviewerbioinformaticsg:Profilerheart–brain axis

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