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Class-aware multi-source domain adaptation algorithm for medical image analysis using reweighted matrix matching

Huiying Zhang1, Yongmeng Li2, Lei He3

  • 1Department of Thoracic Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.

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|July 23, 2025
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Summary

This study introduces a novel Class-Aware Multi-Source Domain Adaptation algorithm (CAMSDA-RMM) to improve medical image analysis by addressing class shift. The method enhances transfer learning effectiveness for complex medical datasets.

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Area of Science:

  • Medical Imaging Analysis
  • Machine Learning
  • Computer Vision

Background:

  • Multi-source domain adaptation (MSDA) enhances transfer learning using multiple data sources, beneficial for complex medical applications.
  • Existing MSDA methods often assume identical class distributions, neglecting the critical issue of class shift in real-world medical data.

Purpose of the Study:

  • To propose a novel Class-Aware Multi-Source Domain Adaptation algorithm based on a Reweighted Matrix Matching strategy (CAMSDA-RMM).
  • To address the challenge of class shift in MSDA for improved medical image analysis.
  • To enhance positive transfer effects and optimize source domain contributions.

Main Methods:

  • Developed a class-aware strategy to strengthen positive transfer between similar classes.
  • Applied first-order and second-order moment matching for effective source and target domain alignment.
  • Implemented an adaptive weighting mechanism to optimize the contribution of each source domain.

Main Results:

  • The proposed CAMSDA-RMM algorithm demonstrated superior performance in classification accuracy and domain adaptability.
  • Experimental validation on four public chest X-ray datasets confirmed the effectiveness of the method.
  • The approach successfully mitigates the impact of class shift in multi-source domain adaptation settings.

Conclusions:

  • CAMSDA-RMM offers a robust solution for multi-source domain adaptation in medical imaging, particularly when class distributions differ.
  • The proposed method improves the reliability and accuracy of AI models in complex medical diagnostic tasks.
  • This work advances the field of domain adaptation by explicitly handling class shift in multi-source scenarios.