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Radiation: Applications01:17

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The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
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Simulation-free radiotherapy on the MR-linac in prostate cancer.

Sian Cooper1,2, Joan Chick3, Francis Casey3

  • 1The Institute of Cancer Research, London, SM2 5NG, United Kingdom.

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|July 23, 2025
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Summary
This summary is machine-generated.

Diagnostic MRI scans can be adapted for "simulation-free" radiotherapy (SFRT) planning in prostate cancer patients, potentially streamlining treatment pathways. This approach uses existing scans, improving efficiency for MRI-guided online adaptive radiotherapy (MRIgART).

Keywords:
MR-LinacMRLSFRUnityprostatesimulation free radiotherapysimulation-free

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Planning

Background:

  • Standard radiotherapy (RT) workflows for prostate cancer treatment planning are often inefficient and face bottlenecks.
  • The integration of magnetic resonance imaging (MRI) in RT planning, particularly MRI-guided online adaptive radiotherapy (MRIgART), offers potential for improved precision.
  • Utilizing diagnostic, non-radiotherapy-dedicated MRI scans could overcome limitations in the current RT planning pathway.

Purpose of the Study:

  • To evaluate the feasibility and safety of "simulation-free" radiotherapy (SFRT) using diagnostic MRI scans for prostate cancer treatment planning.
  • To assess the suitability of existing diagnostic MRI scans for target and organ-at-risk delineation in MRIgART.
  • To quantify potential time savings in the radiotherapy workflow by eliminating the need for a dedicated planning MRI.

Main Methods:

  • Audit of diagnostic MRI scans from prostate cancer patients who received 5-fraction stereotactic body radiotherapy (SBRT).
  • Evaluation of MRI scans for suitability based on T2-weighted sequences and large field-of-view coverage for RT planning.
  • Workflow analysis to measure time intervals from RT referral to the first fraction, comparing with potential SFRT timelines.

Main Results:

  • Diagnostic MRIs were available for 93% of patients, acquired on 1.5T or 3T scanners across various institutions.
  • Initially, 31% of MRIs met ideal image characteristics for RT planning; however, proposed solutions could increase suitability to 87%.
  • Identified issues included cropped field of view and insufficient slice resolution, with technical solutions proposed to mitigate these.

Conclusions:

  • Most diagnostic MRI scans can be adapted for radiotherapy planning with appropriate technical adjustments.
  • The findings support the feasibility of implementing simulation-free radiotherapy (SFRT) by leveraging existing diagnostic imaging.
  • This approach holds promise for optimizing radiotherapy workflows and potentially reducing treatment delivery times.