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Evaluation of P wave and QT interval dispersion in multisystem inflammatory syndrome in children

Eda Naz Ozdemir1, Melike Emiroglu2, Ahmet Sert3

  • 1Department of Pediatrics, Yunak Hacı Izzet Baysal State Hospital, Konya, Turkey.

Journal of Electrocardiology
|July 23, 2025
PubMed

Insights

Children with multisystem inflammatory syndrome (MIS-C) exhibit increased P wave and QT interval dispersion, indicating a higher risk of arrhythmias. This suggests meticulous cardiac monitoring is crucial for hospitalized MIS-C patients.

Area of Science:

  • Pediatric Cardiology
  • Electrophysiology
  • Infectious Diseases

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a serious condition affecting multiple organs.
  • Cardiac involvement is a significant concern in MIS-C, potentially leading to arrhythmias.
  • Understanding electrophysiological changes in MIS-C is vital for risk stratification and management.

Purpose of the Study:

  • To investigate the relationship between P wave dispersion, QT interval dispersion, and corrected QT interval dispersion with clinical pathologies in children with MIS-C.
  • To compare electrophysiological parameters between MIS-C patients and healthy controls.
  • To assess changes in these parameters following treatment for MIS-C.

Main Methods:

  • A cohort of 60 children diagnosed with MIS-C and 26 healthy children were included.
  • 12-lead surface electrocardiography was used to measure maximum and minimum P wave and QT interval durations.
  • Statistical analysis was performed to compare dispersion measures between groups and before/after treatment.

Main Results:

  • P wave dispersion and QT interval dispersion were significantly elevated in children with MIS-C compared to healthy controls (p < 0.001).
  • Both P wave and QT interval dispersion were significantly reduced after treatment in MIS-C patients (p < 0.001).
  • These findings suggest a correlation between increased dispersion and the occurrence of arrhythmias in MIS-C.

Conclusions:

  • Significantly greater P wave and QT dispersion were observed in MIS-C patients versus controls.
  • This increased dispersion correlates with the observed frequency of arrhythmias in MIS-C.
  • Close cardiac monitoring for potential arrhythmias is recommended for all hospitalized MIS-C patients.
Abstract

Keywords:
ArrhythmiaMultisystem inflammatory syndrome in childrenP wave dispersionQT interval dispersion

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