Related Experiment Video

Updated: Sep 14, 2025

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.0K

Cardiac morphologic and functional characteristics in patients with left ventricular excessive Trabeculation versus

Rachel Shatanof1, Sahil Ghay1, Rafle Fernandez2

  • 1Department of Internal Medicine, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL, United States of America.

International Journal of Cardiology
|July 23, 2025
PubMed

Insights

Left ventricular excessive trabeculation (LVET) patients exhibit distinct cardiac mechanics compared to Apical Hypertrophic Cardiomyopathy (ApHCM). LVET is independently linked to superior left ventricular longitudinal function, even with preserved ejection fraction.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Cardiac Mechanics

Background:

  • Left ventricular excessive trabeculation (LVET) and Apical Hypertrophic Cardiomyopathy (ApHCM) share genetic links and left ventricular (LV) predilection.
  • Comparative data between LVET and ApHCM is limited.

Purpose of the Study:

  • To compare cardiac morphologic and functional characteristics between LVET and ApHCM patients.
  • To identify factors associated with LV global longitudinal strain (GLS) in these patient groups.

Main Methods:

  • Retrospective analysis of 16 LVET and 93 ApHCM patients with preserved LV ejection fraction (LVEF).
  • Utilized 2D and speckle-tracking echocardiography to assess LV and right ventricular (RV) mechanics, including GLS and peak twist.
  • Multivariate linear regression identified predictors of LV GLS.

Main Results:

  • LVET patients were younger, predominantly of African-American ethnicity, and had lower rates of hypertension and atrial fibrillation compared to ApHCM.
  • LVET showed significantly better LV GLS and lower peak LV twist than ApHCM.
  • LVET was independently associated with better LV GLS, irrespective of interventricular septal thickness or RV GLS.

Conclusions:

  • Significant differences in cardiac morphology and function exist between LVET and ApHCM patients with preserved LVEF.
  • LVET is independently associated with enhanced LV longitudinal mechanics, suggesting distinct pathophysiological mechanisms.
Abstract

Keywords:
Apical hypertrophic cardiomyopathyCardiac mechanicsGlobal longitudinal strainLeft ventricular excessive trabeculationNon-compaction cardiomyopathyStrain echocardiography

More Related Videos

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

5.8K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

3.9K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
52
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
59
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
45
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
60
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
35
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
37