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Circadian rhythms in ophthalmic diseases.

Wenxiao Zhang1, Shenzhen Huang2

  • 1Department of Ophthalmology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.

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|July 23, 2025
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Circadian rhythms impact eye health and disease. Disruptions to these biological rhythms worsen ophthalmic conditions and treatment outcomes, highlighting the need for circadian-based eye therapies.

Keywords:
ChronotherapyCircadian disruptionCircadian rhythmsDisease progressionOphthalmic diseases

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Area of Science:

  • Ophthalmology
  • Chronobiology
  • Neuroscience

Background:

  • Circadian rhythms, regulated by the suprachiasmatic nucleus, control physiological processes.
  • Ocular function and disease pathogenesis are influenced by these biological rhythms.
  • Altered circadian rhythmicity is observed in various ophthalmic diseases.

Purpose of the Study:

  • To review circadian alterations in common ophthalmic diseases.
  • To explore the link between circadian dysregulation and ocular disorders.
  • To discuss potential circadian-based therapeutic strategies.

Main Methods:

  • Literature review of studies on circadian rhythms and ophthalmic diseases.
  • Analysis of the impact of circadian disruptions on ocular health.
  • Examination of specific eye conditions including dry eye, glaucoma, diabetic retinopathy, AMD, and cataracts.

Main Results:

  • Circadian rhythm dysregulation is strongly associated with the development and progression of ocular disorders.
  • Disrupted circadian homeostasis can exacerbate ophthalmic disease symptoms.
  • Altered circadian rhythmicity affects treatment efficacy and patient quality of life.

Conclusions:

  • Understanding circadian alterations is crucial for elucidating ophthalmic disease mechanisms.
  • Circadian-based interventions hold promise for treating eye diseases.
  • Further research is needed to develop and validate these novel therapeutic approaches.