Highly Preorganized Calixarene Tweezers for Protein Recognition.

Katrin Hommel1, Sebastian Theisen2, Mike Blueggel1

  • 1Molecular Biology II, Center of Medical Biotechnology (ZMB) and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitätsstrasse 5, 45141 Essen, Germany.

Biomacromolecules
|July 23, 2025
PubMed
Summary

Researchers designed calixarene-based inhibitors to target Taspase 1, a cancer-related protease. Rigid, preorganized calixarene tweezers effectively disrupted the Taspase 1/Importin α-interaction, showing promise for enzyme inhibition.

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