Association between time weighted average mechanical power normalized to compliance and prognosis of critically ill patients: A retrospective cohort study based on the MIMIC-IV database

This study aims to evaluate the association of time‑weighted average mechanical power normalized to compliance (TWA-MP_CRS) with all-cause mortality to determine its value as a prognostic tool in intensive care patients.

Retrospective observational study.

Intensive care unit (ICU).

4387 first-time ICU-admitted patients in the Medical Information Mart for Intensive Care (MIMIC) IV.

None.

TWA-MP_CRS, ICU mortality and in-hospital mortality.

Participants' mean age was 61.4 ± 16.9 years and the median [IQR] baseline TWA-MP_CRS was 0.3 (0.2, 0.6) J/min/mL/cmH₂O. When TWA-MP_CRS was divided into quintiles (with quintile 1 representing the lowest values), after adjusting for covariates, the odds ratios [95% confidence intervals (CIs)] for ICU mortality were 1.49 (95% CI: 1.15-1.94), 1.67 (95% CI: 1.29-2.16), 1.79 (95% CI: 1.37-2.33), and 3.96 (95% CI: 3.01-5.21) for quintiles 2, 3, 4, and 5 respectively, with quintile 1 as reference. Similar results were found for hospital mortality.

Higher TWA-MP_CRS is associated with poor clinical outcomes in critically ill patients. Higher TWA-MP_CRS can lead to a higher mortality among ICU and in-hospital patients.