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Related Experiment Video

Updated: Sep 14, 2025

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Hippocampal representations drift in stable multisensory environments.

Jason R Climer^1,2, Heydar Davoudi¹, Jun Young Oh¹

¹Department of Neurobiology, Northwestern University, Evanston, IL, USA.

|July 23, 2025

Summary

This summary is machine-generated.

Neural representations in the hippocampus drift over time. This study shows neuronal excitability predicts representational stability, even in controlled virtual reality environments, highlighting its role in long-term memory.

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Area of Science:

Neuroscience
Cognitive Science
Computational Neuroscience

Background:

Hippocampal place cells form neural representations of environments.
Neural representations exhibit 'representational drift' over days.
The causes of representational drift (intrinsic function vs. environmental/behavioral confounds) are debated.

Purpose of the Study:

To investigate the causes of representational drift in hippocampal place cells.
To determine if controlled environments and behavior eliminate representational drift.
To identify factors predicting long-term representational stability.

Main Methods:

Utilized a multisensory virtual reality system for precise environmental and behavioral control.
Tracked hippocampal place cell activity in mice over multiple days.
Correlated neuronal excitability with the degree of representational drift.

Main Results:

Representational drift persists even in highly reproducible virtual environments.
Differences in sensory input or behavior did not significantly alter drift rate.
Higher neuronal excitability in place cells predicted less subsequent representational drift.

Conclusions:

Representational drift is an intrinsic property of hippocampal place cells, not solely due to environmental or behavioral variability.
Neuronal excitability is a key predictor of long-term stability in neural representations.
Findings advance understanding of memory consolidation and neural plasticity.