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Prognostic implications of complement C1q-like 4 expression in breast cancer
Qing Zhang1, Zhijun Xing2, Lu Bai1
1Departments of Oncology, Affiliated Hospital of Chengde Medical University, Chengde, China.
Scientific Reports
|July 23, 2025
Summary
Higher expression of Complement C1q-like protein 4 (C1ql4) in breast cancer correlates with increased malignancy and poorer patient survival. This protein may serve as a novel biomarker for predicting breast cancer progression and outcomes.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Complement C1q-like protein 4 (C1ql4) is implicated in immune responses and inflammation.
- C1ql4 is expressed across all molecular subtypes of breast cancer.
- Elevated C1ql4 expression may indicate increased tumor malignancy.
Purpose of the Study:
- To investigate the relationship between C1ql4 expression and overall survival in breast cancer patients.
- To evaluate the prognostic value of C1ql4, independently and with clinicopathologic parameters.
- To explore C1ql4 as a potential biomarker for breast cancer malignancy.
Main Methods:
- Retrospective analysis of 111 breast cancer patients undergoing resection.
- Correlation analysis between C1ql4 protein expression and TNM staging/molecular subtypes.
- Survival analysis to assess prognostic value of C1ql4.
Main Results:
- Significant positive association found between C1ql4 expression and TNM staging.
- C1ql4 expression levels differed significantly across molecular subtypes.
- High C1ql4 expression was linked to significantly poorer patient prognoses.
Conclusions:
- C1ql4 expression is associated with breast cancer malignancy and poor prognosis.
- C1ql4 may serve as a potential biomarker for predicting breast cancer progression.
- Further research is warranted to validate C1ql4 as a prognostic indicator.
