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Updated: Sep 14, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
New amino-naphthoic acid derivatives produced by biological transformation using the deep-sea-derived bacterium
Mai Sakaguchi1, Katsuki Kikuchi1, Ryota Okamura1
1Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.
Abstract:
Deep-sea-derived microorganisms are quite attractive as resources for new secondary metabolites, enzymes, and gene discovery. We have isolated many marine microorganisms from deep-sea creatures and screened the new secondary metabolites produced by them. Two new molecules designated amino-naphthoic acid derivatives (1 and 2) were obtained by biological transformation using the deep-sea derived bacterium Serinicoccus marinus KDM482 successfully. Structural analysis using 1D and 2D NMR and MS data revealed that both 1 and 2 were dimerized compounds of 3-amino-2-naphthoic acid. In biological assays, 1 and 2 moderately inhibited the growth of Malme-3M cells.
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