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To what extent is response-adaptive randomization used in clinical trials? A systematic review using Cortellis

Oleksandr Sverdlov1, Jone Renteria2, Kerstine Carter3

  • 1Advanced Quantitative Sciences, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.

Statistical Methods in Medical Research
|July 24, 2025
PubMed
Summary

Response-adaptive randomization (RAR) is increasingly used in adaptive clinical trials. This systematic review details RAR trial characteristics, applications, and positive outcomes, supporting its value in optimizing trial design.

Keywords:
Adaptive designCortellis Regulatory Intelligence databaseclinical trialsmulti-arm trialresponse-adaptive randomization

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