Related Experiment Video
Updated: Sep 14, 2025
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
The Value of Systemic Inflammatory Index and Nutritional Marker in Predicting Acute Calculus Cholecystitis and Its
Bing He1, Qiguang He2, Zhiyong Lai3
1Department of First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China.
Background:
The study aimed to evaluate the accuracy with which various nutritional and inflammatory indicators, including Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Systemic Immune-Inflammation Index (SII), Monocyte-to-Lymphocyte Ratio (MLR), Systemic Inflammatory Response Index (SIRI), and Prognostic Nutritional Index (PNI), can predict the severity of acute calculus cholecystitis.
Methods:
109 cases of chronic calculus cholecystitis (CCC) and 130 cases of acute calculus cholecystitis (ACC), including 62 cases of acute simple cholecystitis (ASC), 35 cases of acute purulent cholecystitis (APC), and 33 cases of acute gangrenous cholecystitis (AGC), were encompassed in the retrospective cohort study. The patients' clinical information and inflammatory-immune markers were collected for analysis.
Results:
The optimal cut-off values for NLR, SIRI, SII, MLR, PLR, and PNI in distinguishing ACC from CCC were determined to be 2.499, 0.964, 593.5, 0.230, 148.0, and 141.3, respectively. NLR > 2.499 demonstrated the highest predictive capability, with an AUC of 0.896. Multivariate analysis indicated that NLR > 2.499 (OR: 4.69, p = 0.006) was the dominant factor in differentiating ACC from CCC. The optimal cut-off values for SII, SIRI, MLR, NLR, PLR, and PNI in distinguishing ASC from APC were 1098, 2.092, 0.304, 4.082, 191.1, and 135.3, respectively. SII > 1098 exhibited the highest predictive capability, with an AUC of 0.73. The optimal cut-off values for NLR, SIRI, MLR, SII, and PLR in differentiating APC from AGC were 7.232, 4.773, 0.557, 2417, and 221.5, respectively. NLR > 7.232 demonstrated the highest predictive capability, with an AUC of 0.826.
Conclusion:
Systemic inflammatory index and nutritional marker can serve as valuable indicators for predicting acute calculus cholecystitis and its severity. An elevated systemic inflammatory index and a declining nutritional marker suggest an increased risk of severe cholecystitis, warranting prompt and appropriate interventions.
Related Concept Videos
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:29Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...