Glioblastoma in Puerto Rico: A 21-year population-based study

Area of Science:

• Neuro-oncology
• Epidemiology
• Public Health

Background:

• Glioblastoma (GBM) is the most common aggressive primary brain tumor in adults.
• Limited epidemiological data exists for GBM in Puerto Rico.
• This study addresses the data gap on GBM in Puerto Rico.

Purpose of the Study:

• To conduct the first population-based analysis of GBM in Puerto Rico.
• To examine GBM incidence, demographics, and geographic distribution.
• To identify epidemiological patterns and temporal trends.

Main Methods:

• Retrospective analysis of 1,423 GBM cases (2000-2020) from the Puerto Rico Central Cancer Registry.
• Inclusion of 1,334 histopathologically confirmed cases.
• Analysis of demographic, clinical, and geographic variables using statistical methods and geolocation mapping.

Main Results:

• The average age-adjusted incidence rate (AAAIR) was 1.78 per 100,000.
• Highest incidence observed in the 65-74 age group.
• Significant upward trend with an annual percentage change (APC) of 4.85%.

Conclusions:

• GBM in Puerto Rico shows distinct epidemiological patterns, including lower incidence than the U.S. mainland.
• Significant geographic variations in incidence were identified.
• Further investigation into environmental, genetic, and socioeconomic factors is warranted.