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Updated: Sep 14, 2025
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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
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Unusual Retroperitoneal Soft Tissue Sarcomas: Giant Masqueraders
Guddi Rani Singh1, Mamta Kumari1, Ayushi Singh1
1Pathology department, IGIMS Patna, India.
Summary
Retroperitoneal soft tissue sarcomas (STS) are rare, with liposarcoma being most common. Accurate diagnosis via histopathology and immunohistochemistry is crucial for managing these uncommon tumors.
Area of Science:
- Oncology
- Pathology
Background:
- Retroperitoneal soft tissue sarcomas (STS) represent a rare subset of adult STS.
- Liposarcoma is the most frequent subtype, while fibrosarcoma and extraskeletal Ewing sarcoma (EES) are significantly rarer.
Observation:
- Three cases are presented: a dedifferentiated liposarcoma in a 76-year-old male, an adult fibrosarcoma in a 69-year-old male, and extraskeletal Ewing sarcoma in a 55-year-old female with metastatic disease.
- Clinical presentation varied, including a large retroperitoneal tumor, retroperitoneal mass, and lumbar pain with weight loss and hepatic metastasis.
Findings:
- Dedifferentiated liposarcoma was diagnosed based on microscopic analysis and positive vimentin and MDM2 markers.
- Adult fibrosarcoma diagnosis was confirmed after excluding other possibilities.
- Extraskeletal Ewing sarcoma was identified through histopathological and immunohistochemical (IHC) analysis.
Implications:
- Comprehensive evaluation including clinical, radiological, histopathological, and IHC examinations is essential for accurate STS subtyping in the retroperitoneum.
- Precise diagnosis significantly impacts patient management and prognosis for rare retroperitoneal sarcomas.
