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Basis for lactose aversion in the weanling rat.

H H Blake, S J Henning

    Physiology & Behavior
    |August 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Weanling rats prefer low-lactose diets over high-lactose diets, even when the latter is sweetened. Post-ingestive factors, not just taste, drive this aversion to high lactose concentration.

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    Area of Science:

    • Nutritional Science
    • Animal Behavior
    • Physiology

    Background:

    • Weanling rats exhibit a preference for a 12% lactose (low-L) liquid diet over an isocaloric 47% lactose (high-L) diet.
    • This preference persists despite the high-L diet being sweeter.

    Purpose of the Study:

    • To investigate the underlying reasons for the aversion to high lactose concentrations in weanling rats.
    • To determine if post-ingestive factors or palatability influence diet choice.

    Main Methods:

    • Rats were presented with a choice between the low-L diet and a saccharin-sweetened high-L diet.
    • Diet preference was monitored over several days of exposure.

    Main Results:

    • Pups initially preferred the saccharin-sweetened high-L diet.

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  • Preference shifted to the low-L diet after several days when it was the alternative choice.
  • This indicates that post-ingestive consequences are a significant factor in high lactose aversion.

    • Conclusions:

    • The aversion to high lactose concentrations is primarily driven by post-ingestive consequences rather than initial palatability.
    • The negative effects of high lactose intake override the preference for sweetness.