Erythema Multiforme-Like Lesions Revealing Systemic Lupus Erythematosus

Rowell syndrome is a rare clinical entity, defined by the association of systemic lupus erythematosus (SLE) and erythema multiforme (EM)-like skin lesions, accompanied by distinctive immunological findings such as a speckled antinuclear antibody (ANA) pattern. It predominantly affects women and requires specific diagnostic criteria. Management depends on the extent and severity of organ involvement. We report the case of a 69-year-old woman who developed severe mucocutaneous erythema multiforme-like lesions and systemic symptoms. Clinical and laboratory findings supported the diagnosis of SLE. Targeted treatment combining corticosteroids and hydroxychloroquine resulted in marked clinical and biological improvement.