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Updated: Sep 14, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Acute generalized exanthematous pustulosis triggered by dupilumab
Caterina Mariarosaria Giorgio1, Giuseppe Argenziano2, Vittorio Tancredi1
1Dermatology Unit, University of Campania, Naples.
None:
Dear Editor, We present a rare but clinically significant case of acute generalized exanthematous pustulosis (AGEP) following the administration of dupilumab in a patient with refractory atopic dermatitis (AD). While dupilumab is widely regarded as a safe and effective biologic agent for moderate-to-severe AD across age groups - including adolescents, adults, and increasingly children - emerging reports underscore the need to remain vigilant for uncommon, severe cutaneous reactions. [...].
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