Related Experiment Video

Updated: May 10, 2026

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood
06:07

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Published on: February 5, 2020

5.8K

Risk factors of immune checkpoint inhibitor-related cardiotoxicity: a scoping review

Yixuan Wang1, Liyan Zhang2, Zhenzhen Su1

  • 1School of Nursing, Peking University, Beijing 100191, China.

The Oncologist
|July 24, 2025
PubMed
Abstract

Insights

Immune checkpoint inhibitor (ICI) cardiotoxicity, though rare, can be fatal. This review identified 60 risk factors, including specific ones like cardiovascular history and renal disease, to aid early detection and intervention.

Area of Science:

  • Oncology
  • Cardiology
  • Immunology

Background:

  • Cardiotoxicity from immune checkpoint inhibitors (ICIs) is a rare but potentially fatal complication in cancer patients.
  • Clinical signs of ICI-related cardiotoxicity are often nonspecific, hindering prompt diagnosis.
  • Identifying high-risk patients is crucial for timely intervention during ICI therapy.

Purpose of the Study:

  • To define the risk factors associated with immune checkpoint inhibitor (ICI)-related cardiotoxicity.
  • To enable early identification of patient groups at higher risk for ICI cardiotoxicity.
  • To facilitate timely interventions for patients undergoing ICI treatment.

Main Methods:

  • A scoping review was conducted following the Arksey and O'Malley framework.
  • A systematic literature search was performed across ten major electronic databases.
  • Data screening and extraction were independently conducted by two reviewers, adhering to PRISMA-ScR guidelines.

Main Results:

  • The review identified 29 studies and 60 distinct risk factors for ICI-related cardiotoxicity.
  • These factors include 25 common immune-related adverse event risks and 5 traditional cardiovascular disease risks.
  • Specific risk factors identified include cardiovascular medical history, renal disease, obstructive sleep apnea, abnormal lab parameters, and cardiovascular medications.

Conclusions:

  • A comprehensive list of 60 risk factors across 3 key areas for ICI-related cardiotoxicity was compiled.
  • Potential underlying mechanisms contributing to ICI cardiotoxicity were discussed.
  • This review provides clinicians with tools to identify at-risk patients for improved prevention, treatment, and outcomes.
Keywords:
cancercardiotoxicityimmune checkpoint inhibitorsrisk factors

More Related Videos

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

4.8K
High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers14:03

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers

Published on: March 24, 2023

2.0K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...