Using the Electronic Grab-Transport Mechanism to Construct Metal-Organic Frameworks with Type I/II Dual Sonodynamic...

Area of Science:

• Biomedical Engineering
• Materials Science
• Cancer Therapy

Background:

• Sonodynamic therapy (SDT) shows promise for tumor treatment but is limited by tumor hypoxia.
• Existing oxygen-dependent sonosensitizers (SSs) are susceptible to hypoxic conditions, reducing their efficacy.

Purpose of the Study:

• To develop a novel porphyrin-based metal-organic framework (Yb-TCPP PMOF) with dual type I/II SDT actions.
• To enhance SDT efficacy by addressing tumor hypoxia and improving reactive oxygen species (ROS) generation.

Main Methods:

• Constructed Yb-TCPP PMOF with dual type I/II SDT actions by regulating electron transfer.
• Loaded Au nanoparticles onto Yb-TCPP to enhance ROS yield and electron transport via the EGT effect.
• Developed a self-producing oxygen circulation system (Au/Yb-TCPP@GOx) using Au nanoparticles as catalase and glucose oxidase.

Main Results:

• Au/Yb-TCPP exhibited reduced band gap and abundant oxygen vacancies, enhancing electron-hole separation and SDT efficiency.
• The Au/Yb-TCPP@GOx system alleviated tumor hypoxia and induced a starvation effect on tumor cells.
• In vitro and in vivo studies confirmed effective tumor inhibition by Au/Yb-TCPP@GOx through enhanced SDT and starvation therapy.

Conclusions:

• The developed Au/Yb-TCPP@GOx composite material offers a synergistic approach to enhance SDT efficacy.
• This strategy effectively overcomes tumor hypoxia and improves ROS generation for cancer treatment.
• The findings provide guidance for improving electron transport, alleviating tumor hypoxia, and developing starvation-based cancer therapies.