Systemic inflammatory response index as a predictive biomarker for Irvine-Gass syndrome

Area of Science:

• Ophthalmology
• Immunology
• Medical Diagnostics

Background:

• Irvine-Gass Syndrome (IGS), or pseudophakic cystoid macular edema, is a complication following cataract surgery.
• Systemic inflammation may play a role in the development of IGS.
• Evaluating systemic inflammatory markers could offer insights into IGS pathogenesis.

Purpose of the Study:

• To assess systemic inflammatory marker levels in patients with IGS.
• To compare these markers with those in uncomplicated cataract cases (controls).
• To determine the potential of these markers as predictors for IGS.

Main Methods:

• Retrospective analysis of 25 IGS cases and 30 control cases.
• Measurement of neutrophil, monocyte, lymphocyte, and thrombocyte counts.
• Calculation and comparison of systemic inflammatory markers: neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI).
• Receiver operating characteristic (ROC) curve analysis to identify optimal cutoff values for predictive markers.

Main Results:

• The systemic inflammatory response index (SIRI) was significantly higher in the IGS group compared to controls (p=0.036).
• While NLR, PLR, and SII were higher in the IGS group, the differences did not reach statistical significance.
• ROC analysis indicated an area under the curve of 0.665 for SIRI, with an optimal cutoff of 0.95 (64% sensitivity, 73% specificity) for distinguishing IGS.

Conclusions:

• Elevated SIRI levels in IGS cases suggest a potential association between subclinical systemic inflammation and the development of pseudophakic cystoid edema.
• SIRI demonstrates potential utility as a predictive factor for identifying patients at risk of IGS after cataract surgery.