Metabolic reprogramming and functional crosstalk within the tumor microenvironment (TME) and A Multi-omics anticancer...

Area of Science:

• Oncology
• Cancer Metabolism
• Systems Biology

Background:

• Tumors exhibit complex cellular compositions influencing their metabolic microenvironment.
• Metabolic interactions like nutrient competition and exchange are critical within the tumor microenvironment (TME).
• Cancer cells display metabolic flexibility, aiding survival in harsh conditions like hypoxia.

Purpose of the Study:

• To review the metabolic symphony within the tumor microenvironment (TME).
• To explore tumor metabolism intricacies using multi-omics methodologies.
• To discuss prospects for innovative cancer therapeutic strategies targeting metabolic crosstalk.

Main Methods:

• Integration of multi-omics data, including genomics, transcriptomics, proteomics, and metabolomics.
• Analysis of metabolic heterogeneity within tumors.
• Investigation of intra- and extra-tumoral metabolic connections.

Main Results:

• Tumors possess inherent metabolic heterogeneity.
• Multi-omics approaches provide comprehensive insights into tumor metabolism.
• Identification of key metabolic pathways and regulatory networks driving tumor progression.

Conclusions:

• Understanding metabolic crosstalk in the TME is crucial for cancer progression.
• Multi-omics methodologies offer a holistic view of tumor metabolism.
• Targeting metabolic vulnerabilities presents a promising avenue for novel cancer therapeutics.