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Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

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Published on: November 16, 2011

Classically conditioned hyperglycemia in the obese mouse.

R S Surwit, J A McCubbin, E G Livingston

Psychosomatic Medicine

|November 1, 1985

Summary

This summary is machine-generated.

Obese diabetic mice can develop stress-induced hyperglycemia through classical conditioning. This study shows obese mice, but not lean mice, learned to associate a metronome with stress, leading to conditioned hyperglycemia.

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Published on: November 16, 2011

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Area of Science:

Endocrinology
Animal Models
Behavioral Science

Background:

The obese (C57BL/6J ob/ob) mouse is a standard model for non-insulin-dependent diabetes mellitus.
This model requires environmental stress to consistently exhibit hyperglycemia.
Stress-induced hyperglycemia is a known physiological response.

Purpose of the Study:

To investigate the potential for classical conditioning to induce hyperglycemia in obese mice.
To determine if obese mice exhibit conditioned stress responses differently than lean mice.

Main Methods:

Obese diabetic and lean control mice were exposed to shaking stress.
Classical conditioning was induced by pairing a metronome with shaking stress.
Control groups received non-contingent or no stress exposure.
Blood glucose levels were measured after exposure to the metronome alone.

Main Results:

All animals showed hyperglycemia in response to direct shaking stress.
Obese mice demonstrated classical conditioning, developing hyperglycemia when exposed to the metronome alone.
Lean mice did not show conditioned hyperglycemia.

Conclusions:

Classical conditioning can induce hyperglycemia in the obese mouse model.
Obese mice exhibit a greater capacity for conditioned stress hyperglycemia compared to lean mice.
This finding has implications for understanding diabetes pathophysiology and stress responses.