Surgical Versus Nonsurgical Management of Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Surgical management of pancreatic neuroendocrine tumors (PNETs) significantly improves overall survival compared to nonsurgical approaches. However, for very small, asymptomatic PNETs, nonsurgical options may be considered.
Area Of Science
- Oncology
- Surgical Oncology
- Gastroenterology
Background
- Pancreatic neuroendocrine tumors (PNETs) are rare cancers.
- Surgical resection is a primary treatment, but its optimal role is debated.
Purpose Of The Study
- To compare the effectiveness of surgical versus nonsurgical management for PNETs.
- To analyze survival outcomes in patients with PNETs undergoing different treatment modalities.
Main Methods
- Systematic literature search of Medline, Scopus, Web of Science, and Embase databases.
- Meta-analysis of 77 studies including 62,654 patients comparing surgical and nonsurgical PNET management.
- Primary endpoint was overall survival; subgroup analyses included tumor grade, size, and functional status.
Main Results
- Surgical management was associated with a significantly lower mortality risk (HR 0.30, P < 0.001).
- Improved 1-, 3-, 5-, and 10-year survival rates were observed in surgically treated patients.
- Surgical intervention showed survival benefits across various PNET subtypes, except for PNETs < 1 cm.
Conclusions
- Surgical management offers superior outcomes for resectable PNETs and should be the primary consideration.
- Nonsurgical management is a viable option for select patients with small (<1 cm), asymptomatic PNETs.
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