Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sensitization or tolerance to morphine effects after repeated stresses.

G Benedek, M Szikszay

    Progress in Neuro-Psychopharmacology & Biological Psychiatry
    |January 1, 1985
    PubMed
    Summary

    Stress type impacts morphine effectiveness. Painful stress enhances morphine

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The role of high-energy phonons in electron-phonon interaction at conducting surfaces with helium-atom scattering.

    Physical chemistry chemical physics : PCCP·2022
    Same author

    Prominence of Terahertz Acoustic Surface Plasmon Excitation in Gas-Surface Interaction with Metals.

    The journal of physical chemistry letters·2021
    Same author

    Caffeine - treat or trigger? Disparate behavioral and long-term dopaminergic changes in control and schizophrenia-like Wisket rats.

    Physiology & behavior·2021
    Same author

    Evidence for a spin acoustic surface plasmon from inelastic atom scattering.

    Scientific reports·2021
    Same author

    Large-scale implementation of pooled RNA extraction and RT-PCR for SARS-CoV-2 detection.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
    Same author

    A multimodal pathway including the basal ganglia in the feline brain.

    Physiology international·2019

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Repeated stress exposure can alter drug responses.
    • Understanding stress-induced changes in opioid sensitivity is crucial for pain management.

    Purpose of the Study:

    • To investigate how different types of prolonged stress affect morphine's analgesic and thermoregulatory properties in rats.
    • To determine if stress-induced sensitization or tolerance to morphine occurs.

    Main Methods:

    • Rats underwent 10 days of footshock, acoustic stress, cold water swim, or restraint.
    • Morphine's effects on analgesia (hot-plate and tail-flick tests) and body temperature were assessed on day 11.
    • Dose-dependent responses to morphine (2, 4, 8 mg/kg) were analyzed.

    Main Results:

    • Footshock and acoustic stress sensitized rats to morphine's analgesic and thermoregulatory effects.
    • Restraint stress induced tolerance to morphine.
    • Cold water swim produced mixed results, depending on the morphine dose.

    Conclusions:

    • The sensory nature of stress dictates changes in morphine sensitivity; painful stress leads to sensitization, while non-painful stress leads to tolerance.
    • Enhanced analgesic and thermoregulatory effects suggest a convergence point in the neural pathways mediating these morphine actions.
    • These findings highlight the complex interplay between stress, opioid analgesia, and thermoregulation.

    Related Experiment Videos