Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term outcomes and prognosis of mixed cryoglobulinaemia: a European multicentre study of 1294 patients.

Rheumatology (Oxford, England)·2026

Same author

Distinct Molecular Pathways Supporting Sjögren Disease Clusters and Disease Progression.

Arthritis & rheumatology (Hoboken, N.J.)·2026

Same author

Leflunomide-hydroxychloroquine: a replicable hope in Sjögren's disease?

The Lancet. Rheumatology·2026

Same author

PD1<sup>+</sup> TIGIT<sup>+</sup> CD4<sup>+</sup> T cells predict response to anti-TNF in rheumatoid arthritis and spondyloarthritis.

RMD open·2026

Same author

Is Sjögren's disease the overlooked connective tissue disease associated with a hypersensitivity pneumonitis pattern?

American journal of respiratory and critical care medicine·2026

Same author

The SjD Map: an interactive pathway tour into Sjögren's disease signalling mechanisms.

NPJ systems biology and applications·2026

Search research articles

Related Experiment Video

Updated: Sep 14, 2025

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

Lessons from organoid engineering for rheumatic disease.

Loïc Meudec¹, Negaar Goudarzi², Xavier Mariette¹

¹Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Inserm UMR 1184, Le Kremlin-Bicêtre, France; Department of Immuno-rheumatology, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Joint Bone Spine

|July 24, 2025

Summary

This summary is machine-generated.

Organoids, 3D stem cell models, are revolutionizing translational research for rheumatic diseases like osteoarthritis and rheumatoid arthritis. These models offer new avenues for disease understanding and drug discovery.

Keywords:

Organoids Rheumatic disease Rheumatoid arthritis Sjögren disease Translational research.

More Related Videos

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

Related Experiment Videos

Last Updated: Sep 14, 2025

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

Area of Science:

Biomedical Engineering
Stem Cell Biology
Rheumatology

Background:

Organoids are advanced 3D culture models derived from stem cells.
They replicate the structure and function of human organs.
Organoid technology is a rapidly advancing area in translational research.

Purpose of the Study:

To review the establishment of organoid cultures.
To explore the development of 3D organoid models for rheumatic diseases.
To discuss the potential applications of organoids in rheumatology.

Main Methods:

Literature review on organoid development.
Focus on organoid applications in rheumatic disease research.
Analysis of current and future potential of 3D cultures.

Main Results:

Organoid models have been successfully developed for various organs.
Initial applications in rheumatic diseases include osteoarthritis, rheumatoid arthritis, and Sjögren disease.
Organoids show promise for disease modeling and drug screening.

Conclusions:

Organoid technology is a key emerging model in translational research.
Significant progress has been made in applying organoids to rheumatic diseases.
Organoids hold potential for advancing regenerative medicine and therapeutic development in rheumatology.