Altered breathing pattern and thoracic mobility in women with fibromyalgia: A case-control study

The objective of this study was to investigate respiratory parameters, including minute ventilation, tidal volume, and respiratory rate, and the role of thoracic mobility in women with FM compared to healthy controls. This case-control study included 38 women with fibromyalgia and 44 age-matched healthy women. Respiratory rate was measured using a portable monitor and tidal volume was assessed through spirometry. The minute ventilation was calculated by multiplying tidal volume by respiratory rate. Thoracic mobility was evaluated by measuring chest expansion. Pressure pain threshold was assessed over paraspinal muscles between C7-T7 by algometry to evaluate pain sensitivity. Perceived stress was assessed using the questionnaire Perceived Stress Scale -10. Women with fibromyalgia exhibited significantly higher minute ventilation (p<0.032), respiratory rate (p<0.001), and lower tidal volume (p<0.001) compared to healthy controls. Thoracic mobility was reduced in participants with fibromyalgia. Group differences in minute ventilation disappeared when adjusting for perceived stress, suggesting a psychological influence on respiratory parameters. However, differences in respiratory rate and tidal volume were still significant. Fibromyalgia is associated with altered breathing function, including higher respiratory rate and lower tidal volume. Thoracic mobility and stress may contribute to these changes. PERSPECTIVE: Compared to healthy controls, women with fibromyalgia exhibit an altered breathing pattern which consists of higher minute ventilation due to increased respiratory rate. Reduced thoracic mobility and perceived stress may contribute to this condition. Including the respiratory system in the evaluation and treatment may optimize the effects of rehabilitation. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov: NCT04098731.