Related Experiment Video
Updated: Sep 14, 2025
Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples
Published on: May 19, 2020
Anti-TB treatment non-adherence predictors: A multi-center cross-sectional study in Kandahar, Afghanistan
Muhammad Haroon Stanikzai1, Mohammad Hashim Wafa2, Ahmad Haroon Baray1
1Department of Public Health, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.
Background:
Adherence to anti-TB treatment in low- and middle-income countries (LMICs), including Afghanistan, is critical for global TB control.
Objectives:
We aimed to determine anti-TB treatment non-adherence prevalence and its predictors in Kandahar, Afghanistan.
Methods:
We conducted a multi-center cross-sectional study of 579 TB patients in Kandahar, using a systematic random sampling method, and collected their data on sociodemographic attributes, clinical factors, and mental health. The eight-item Tuberculosis Medication Adherence Questionnaire (TBMAQ) was used for labeling TB patients as adherent or non-adherent. We assigned a score of ≤4 (the cut-off) as non-adherence. We performed the multivariable logistic regression to probe significant predictors of non-adherence.
Results:
The non-adherence rate in this study was 66.8% (95% CI: 62.9-70.5). Being uneducated (AOR = 1.66, 95 % CI: 1.09-2.53), having a comorbid medical condition (AOR = 2.57, 95 % CI: 1.39-4.74), feeling stigmatized for having TB (AOR = 9.25, 95 % CI: 4.72-18.1), and having a comorbid depression (AOR = 1.77, 95 % CI: 1.16-2.71) were associated with non-adherence.
Conclusion:
Anti-TB treatment adherence needs to be prioritized among TB patients overall, particularly in those with a low level of education, comorbidity, perceived TB-related stigma, and comorbid depression with consistent evidence of increased non-adherence.
Related Concept Videos
01:28Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
01:29Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:26Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:31Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
01:28Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...