Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

What is Genetic Engineering?

What is Genetic Engineering?

In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mental health status of workers in the semiconductor industry during the COVID-19 pandemic: comparisons between regions on three continents.

Frontiers in public health·2026

Same author

The comet assay as a tool for human biomonitoring of exposure to environmental and occupational agents - A summary of systematic reviews and meta-analyses.

Mutation research. Reviews in mutation research·2026

Same author

CANLead: Canada as a Phase 1 Clinical Trial Leader - Opportunities, Initiatives, and Collaborative Innovation to Elevate National Competitiveness.

The oncologist·2026

Same author

The comet assay as a tool in human biomonitoring exposure to antineoplastic drugs - A systematic review and meta-analysis.

Mutation research. Reviews in mutation research·2026

Same author

Towards a validation of the standard and enzyme-linked comet assay: a retrospective variability analysis.

Archives of toxicology·2026

Same author

The comet assay as a tool in human biomonitoring exposure to anaesthetic gases - A systematic review and meta-analysis.

Mutation research. Reviews in mutation research·2026

Same journal

Evaluation and interpretation of chemical genotoxicity risks; Strategies for method development.

Mutation research. Genetic toxicology and environmental mutagenesis·2026

Same journal

Oxide-nanoparticles induce in vitro DNA damage and genomic instability in human peripheral blood cells.

Mutation research. Genetic toxicology and environmental mutagenesis·2026

Same journal

LA-COMET group: In vivo application of the comet assay in animal and plant models, including wild species.

Mutation research. Genetic toxicology and environmental mutagenesis·2026

Same journal

Evaluation of applicability of the repeated-dose liver micronucleus assay in rats initiated at８weeks of age as in vivo genotoxicity assessment for 2,6-dninitrotoluene (2,6-DNT), a compound with reported cytostatic potential.

Mutation research. Genetic toxicology and environmental mutagenesis·2026

Same journal

Biomarkers and bioindicators of genotoxicity assessment of solid waste emissions from India: Insights into mechanisms of its genome instability.

Mutation research. Genetic toxicology and environmental mutagenesis·2026

Same journal

Alkaline comet assay in human biomonitoring studies by the Latin America / LA-COMET group.

Mutation research. Genetic toxicology and environmental mutagenesis·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 14, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Significant new developments in genetic toxicology testing

Miroslav Mišík¹, P David Josephy², Helga Stopper³

¹Center for Cancer Research, Medical University of Vienna, Borschkegasse 8a, Vienna 1090, Austria.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis

|July 24, 2025

Summary

No abstract available in PubMed .

More Related Videos

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans

Published on: February 22, 2015

The Lambda Select cII Mutation Detection System

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

Related Experiment Videos

Last Updated: Sep 14, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans

Comprehensive Assessment of Germline Chemical Toxicity Using the Nematode Caenorhabditis elegans

Published on: February 22, 2015

The Lambda Select cII Mutation Detection System

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018