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Updated: Sep 14, 2025

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
Published on: November 22, 2014
Efficient bit labeling in factorization machines with annealing for traveling salesman problem
Shota Koshikawa1, Aruto Hosaka2, Tsuyoshi Yoshida2
1Information Technology R&D Center, Mitsubishi Electric Corporation, Kanagawa, 247-8501, Japan. Koshikawa.Shota@ds.MitsubishiElectric.co.jp.
This study explores binary labeling methods for optimization problems. Gray labeling improves convergence speed and accuracy for the Traveling Salesman Problem (TSP) by reducing local minima.
Area of Science:
- Computational Mathematics
- Machine Learning
- Operations Research
Background:
- Efficiently solving large-scale optimization problems requires converting parameters into machine-readable variables.
- Quadratic unconstrained binary optimization (QUBO) is a key technique, often employing machine learning models like factorization machines with annealing.
- The choice of binary labeling method significantly impacts cost function shape and susceptibility to local minima.
Purpose of the Study:
- To investigate how different binary labeling methods affect the convergence speed and accuracy of optimization algorithms.
- To evaluate the performance of a novel labeling strategy, Gray labeling, in solving optimization problems.
Main Methods:
- The study focuses on quadratic unconstrained binary optimization (QUBO) problems.
- Numerical simulations were performed using the Traveling Salesman Problem (TSP) as a benchmark.
- Gray labeling was proposed and compared against natural labeling for binary variable conversion.
Main Results:
- Gray labeling demonstrated a reduced percentage of local minima compared to natural labeling.
- The proposed Gray labeling resulted in shorter traveling distances for the TSP instances simulated.
- Performance was evaluated within a limited number of iterations, highlighting efficiency gains.
Conclusions:
- Binary labeling methods critically influence the performance of QUBO solvers.
- Gray labeling offers a superior approach for TSP and potentially other optimization problems by minimizing local optima.
- This research provides a valuable method for enhancing machine learning-based optimization strategies.
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