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Zoledronic acid-induced acute psychiatric disorder
Ya-Jun Xiao1, Yu-Yu Zhou1, Yan-Qun Liu2
1Department of Geriatrics, The Third Hospital of Mianyang, Sichuan Mental Health Center, Jiannan Road, Youxian District, Mianyang, Sichuan, China.
Abstract:
As a bisphosphonate drug, zoledronic acid is widely used in the treatment of osteoporosis, hypercalcemia, Paget's disease, and solid malignant tumors. Common adverse reactions include acute-phase responses such as myalgia, fatigue, arthralgia, and fever, while psychiatric disorders have been infrequently reported. This paper presents a case of acute psychiatric disorder in an osteoporotic patient following intravenous infusion of zoledronic acid for the first time, underscoring the necessity of clinical vigilance regarding such rare adverse reactions during treatment.
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