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From the laboratory to the clinic: advancing helminthic therapy for type 2 diabetes

Y Zhu1, X Fei1, R Wang1

  • 1Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, https://ror.org/0331z5r71Zhejiang Shuren University, Hangzhou, China.

Journal of Helminthology
|July 25, 2025
PubMed

Insights

Helminth infections may impact type 2 diabetes (T2D) by altering metabolism and immune responses. Research explores helminths as a potential therapy for T2D, but more clinical studies are needed to confirm safety and effectiveness.

Area of Science:

  • Immunology
  • Metabolic Disorders
  • Parasitology

Background:

  • Type 2 Diabetes (T2D) is a growing global health concern.
  • The interplay between helminth infections and T2D is an emerging research area.
  • Helminths may influence host metabolism and immune regulation relevant to T2D.

Purpose of the Study:

  • To systematically review the effects of helminthic infections on metabolism and immune regulation in T2D.
  • To explore the potential therapeutic role of helminths in managing T2D.
  • To discuss the translation of helminth therapy from research to clinical practice.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of mechanisms mediating direct and indirect effects of helminths.
  • Evaluation of current research on helminth therapy for T2D.

Main Results:

  • Helminth infections can modulate host metabolic pathways and immune responses.
  • Preliminary evidence suggests a potential therapeutic role for helminths in T2D.
  • The mechanisms of helminth-T2D interaction are complex, involving both direct and indirect effects.

Conclusions:

  • Helminth therapy shows promise for T2D management by modulating metabolism and immunity.
  • Translating helminth therapy to clinical application faces challenges.
  • Larger-scale clinical studies are required to validate the safety and efficacy of helminth therapy for T2D patients.
Keywords:
Type 2 diabetes (T2D)clinical applicationhelminthic therapyimmune regulationtranslational research

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