Thyroglobulin-to-tumor volume ratio combined with ultrasound features for diagnosing thyroid follicular neoplasms
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View abstract on PubMed
Summary
This summary is machine-generated.The thyroglobulin-to-tumor volume ratio (Tg/Vol ratio) and contrast-enhanced ultrasound (CEUS) features improve differentiation of follicular thyroid adenoma from carcinoma. This combined model enhances preoperative diagnosis of follicular thyroid carcinoma (FTC).
Area Of Science
- Endocrinology and Thyroidology
- Diagnostic Imaging
- Surgical Pathology
Background
- Preoperative diagnostics often fail to reliably distinguish benign follicular thyroid adenoma (FTA) from malignant follicular thyroid carcinoma (FTC).
- Accurate differentiation is crucial for appropriate patient management and surgical planning.
Purpose Of The Study
- To evaluate the diagnostic utility of thyroid function markers and contrast-enhanced ultrasound (CEUS) features in differentiating FTA from FTC.
- To investigate the novel thyroglobulin-to-tumor volume ratio (Tg/Vol ratio) as a preoperative discriminator.
Main Methods
- Retrospective analysis of 432 resected thyroid follicular neoplasms.
- Comparison of baseline characteristics, thyroid function profiles, and CEUS features between FTA and FTC groups using logistic regression.
- Receiver operating characteristic (ROC) curve analysis for diagnostic performance assessment.
- Development of a multivariate diagnostic model integrating Tg/Vol ratio and CEUS characteristics.
Main Results
- Independent predictors of FTC included capsular involvement, Tg/Vol ratio >7.412, and male gender.
- Higher FTC prevalence observed in patients with elevated serum thyroglobulin (Tg) and Tg/Vol ratio.
- The combined diagnostic model achieved 69.4% sensitivity, 77.0% specificity, with an Area Under the Curve (AUC) of 0.769.
Conclusions
- The Tg/Vol ratio is a more robust preoperative discriminator for follicular thyroid carcinoma than elevated serum Tg alone.
- A combined diagnostic model incorporating the Tg/Vol ratio and CEUS features significantly enhances the accuracy of FTC detection.
- Improved preoperative differentiation can lead to more tailored treatment strategies for thyroid follicular neoplasms.
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