Cell Death-Related Genesets Activity Improved Clinical Concordance and Intrinsically Associated with Alterations in Ulcerative Colitis: Mucosal Healing at Molecular Depth
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View abstract on PubMed
Summary
This summary is machine-generated.Cell death-related genesets (CDRGs) improve ulcerative colitis (UC) management by predicting mucosal healing. This grouping enhances concordance between clinical, histological, and endoscopic assessments, identifying patients for long-term treatment targets.
Area Of Science
- Gastroenterology
- Molecular Biology
- Immunology
Background
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing and remitting cycles.
- Mucosal healing is a critical predictor of long-term outcomes in UC.
- Discordance between mucosal healing at different depths and clinical activity complicates UC management.
Purpose Of The Study
- To analyze cell death-related genesets (CDRGs) in UC patients.
- To assess the concordance between CDRG-based grouping and clinical, histological, and endoscopic assessments.
- To evaluate the predictive value of CDRGs for mucosal healing and long-term treatment targets in UC.
Main Methods
- Unsupervised hierarchical clustering was used to group UC patients based on CDRGs.
- Concordance was assessed using Cohen's Kappa and Sankey plots.
- Predictive value was quantified using the area under the curve; subgroup analysis and single-cell analysis were performed.
Main Results
- CDRG activities effectively predicted clinical, histological, and endoscopic grouping in UC.
- CDRG-based grouping improved concordance across different assessment methods and independently predicted clinical activity.
- Integrating CDRG grouping with endoscopic or histological data enhanced prediction of clinical activity and identified patients achieving mucosal healing.
Conclusions
- CDRG-based grouping serves as an independent predictor, improving concordance in UC assessments and identifying patients achieving mucosal healing.
- Active CDRGs are intrinsically associated with genetic and immunological alterations in UC.
- CDRGs hold potential as novel biomarkers and therapeutic targets for UC.
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