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Related Experiment Video

Updated: Sep 14, 2025

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
05:01

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

10.6K

Murine model for investigating severe trauma.

Rui Li1,2,3, Jing Zhou1,2,3, Wei Huang1,2,3

  • 11Trauma Treatment Center, Peking University People's Hospital, Beijing 100044, China.

World Journal of Emergency Medicine
|July 25, 2025
PubMed
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Researchers developed a stable mouse model for severe trauma, including fractures and blood loss. This reproducible model mimics trauma responses and aids future research into critical injuries.

Area of Science:

  • Trauma research
  • Animal modeling
  • Physiological response to injury

Background:

  • Severe trauma research is limited by the absence of stable, easy-to-use animal models.
  • Developing a reliable model is crucial for advancing trauma studies.

Purpose of the Study:

  • To create a mouse model that accurately reflects the pathophysiological conditions of severe trauma.
  • To provide a dependable tool for scientific investigation in trauma research.

Main Methods:

  • Established a severe trauma model in male C57BL/6J mice.
  • Inducted femoral fractures, exposed abdominal organs, and controlled blood loss (30-50%).
  • Monitored survival rates, physiological parameters, and organ damage.

Main Results:

Keywords:
Murine modelSevere traumaShockSystemic inflammatory response

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Last Updated: Sep 14, 2025

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Published on: August 16, 2019

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Pseudofracture: An Acute Peripheral Tissue Trauma Model
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A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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  • Mice with 30% blood loss showed stable survival, while higher blood loss decreased survival rates.
  • Mean arterial pressure and body temperature initially dropped but recovered.
  • Elevated inflammatory markers and organ injuries were observed.

Conclusions:

  • The developed mouse model effectively replicates severe trauma responses.
  • The model demonstrates stability and reproducibility for trauma research.
  • This tool is valuable for future investigations into severe trauma.