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Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview
Zijin Lin1, Stephen Pandol2, Minoti Apte3
1College of osteopathic medicine, Michigan State University, East Lansing, MI, United States.
Frontiers in Physiology
|July 25, 2025
Summary
Managing chronic pancreatitis pain is complex, impacting quality of life and leading to opioid dependence. This review explores pain mechanisms and multidisciplinary treatments for better patient outcomes.
Area of Science:
- Gastroenterology and Pain Medicine
- Explores the complex mechanisms and management of chronic pancreatitis pain.
Background:
- Chronic pancreatitis (CP) pain significantly reduces patient quality of life, daily function, and mental well-being.
- CP pain contributes to frequent hospitalizations, opioid dependence, and socioeconomic burden.
Purpose of the Study:
- To review the multifaceted nature of CP-related pain.
- To highlight current and emerging management strategies for CP pain.
Main Methods:
- Literature review focusing on CP pain pathogenesis and treatment modalities.
- Analysis of neurogenic inflammation, neuroplasticity, and pain modulation pathways.
- Examination of pharmacologic, endoscopic, surgical, and nerve-targeted interventions.
Main Results:
- CP pain involves complex mechanisms including neurogenic inflammation and disrupted pain modulation.
- Multidisciplinary approaches combining lifestyle changes, medications, procedures, and surgery are current standards.
- Advances in genetics and biomarkers are enabling precision medicine for CP pain.
Conclusions:
- Effective CP pain management requires tailored, interdisciplinary care.
- Understanding intricate pain mechanisms is crucial for improving patient outcomes.
- Emerging innovations offer new hope for refractory CP pain.
Keywords:
central sensitisationchronic pancreatitisneurogenic inflammationpain managemantquality of lifeMore Related Videos
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