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Updated: Sep 14, 2025

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
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Lamins regulate cancer cell plasticity and chemosensitivity.

Guofang Chen1, Tingyi Wei2,3, Ao Huang1

  • 1Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Frontiers in Oncology
|July 25, 2025
PubMed
Summary

Nuclear lamin deficiency disrupts cancer cell plasticity, hindering tumor growth and recurrence. This finding offers a novel strategy to enhance anti-cancer therapy effectiveness by targeting cancer cell behavior.

Keywords:
HIF-1 signalingPD-L1cancer cell plasticitychemosensitivitylamin

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Area of Science:

  • Cellular biology
  • Cancer research
  • Immunology

Background:

  • Cancer cell plasticity drives recurrence and metastasis, posing challenges for anti-tumor therapies.
  • Understanding cancer cell plasticity is crucial for developing effective cancer treatments.

Purpose of the Study:

  • To investigate the role of nuclear lamins in cancer cell plasticity and tumorigenesis.
  • To explore novel therapeutic strategies targeting cancer cell plasticity.

Main Methods:

  • Established stable cancer cell lines with knockdown of all lamin subtypes.
  • Evaluated the effects of lamin deficiency on cancer plasticity and tumor progression in vitro and in vivo mouse models.

Main Results:

  • Lamin knockdown disrupted cancer cell plasticity, stemness, and cell cycle progression.
  • Lamin deficiency modulated DNA damage/repair, mitochondrial function, and induced senescence.
  • Cancer growth in vivo was suppressed by lamin knockdown, enhancing T cell infiltration and activation.
  • Lamin knockdown reduced immune checkpoints and inflammatory factors via HIF-1 signaling, increasing chemotherapy sensitivity.

Conclusions:

  • Nuclear lamins are significant regulators of cancer cell plasticity.
  • Targeting nuclear lamins presents a promising approach to improve anti-cancer therapy efficacy.