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Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute
Lixiao Sun1, Yuxin Fu1, Jiecheng Yang2
1Department of Critical Care Medicine, Handan Central Hospital, Handan, China.
Background:
Prokineticin 2 is associated with the macrophages-mediated biological process, neuronal death, oxidative stress, and inflammatory processes, while its clinical value in patients with acute ischemic stroke (AIS) has not been explored. This study aimed to evaluate the level of prokineticin 2 and its association with inflammatory indexes and functional recovery in AIS patients.
Methods:
Serum samples in 210 AIS patients at admission and in 30 healthy subjects at enrollment were collected. Then, prokineticin 2 levels were determined by enzyme-linked immunosorbent assay.
Results:
Prokineticin 2 level was higher in AIS patients than healthy subjects (p < 0.001). Prokineticin 2 showed an acceptable ability to distinguish the AIS patients from healthy subjects (area under the curve: 0.812) with the best cut-off value at 4 ng/mL. No matter dividing the prokineticin 2 by continuous variable or quartiles, its value was positively correlated with the high sensitivity C reactive protein (HsCRP), tumor necrosis factor-alpha (TNF-α), and interleukin 17A (IL-17A) (all p < 0.001). Prokineticin 2 showed a higher trend in AIS patients with Modified Rankin Scale (mRS) score>2 compared with those with mRS score ≤2, but without statistical significance (p = 0.095). Besides, there was no association between prokineticin 2 by quartiles and the percentage of mRS > 2 (p > 0.05).
Conclusion:
Prokineticin 2 aberrantly highly expresses, and it indicates the inflammatory status, but with limited ability to predict the neural functional recovery in AIS patients.
Insights
Prokineticin 2 is elevated in acute ischemic stroke (AIS) patients and correlates with inflammation markers. However, it has limited predictive value for functional recovery in AIS.
Area of Science:
- Neuroscience
- Immunology
- Biochemistry
Background:
- Prokineticin 2 (PK2) is implicated in inflammatory and neurodegenerative processes.
- Its role in acute ischemic stroke (AIS) remains uninvestigated.
Purpose of the Study:
- To evaluate PK2 levels in AIS patients.
- To assess the association between PK2, inflammatory markers, and functional outcomes.
Main Methods:
- Serum PK2 levels were measured using ELISA in 210 AIS patients and 30 healthy controls.
- Correlations with inflammatory indexes (HsCRP, TNF-α, IL-17A) and functional recovery (mRS) were analyzed.
Main Results:
- AIS patients exhibited significantly higher PK2 levels than controls (p < 0.001).
- PK2 levels positively correlated with HsCRP, TNF-α, and IL-17A (p < 0.001).
- A trend for higher PK2 in patients with poorer functional outcomes (mRS > 2) was observed, but not statistically significant (p = 0.095).
Conclusions:
- Prokineticin 2 is upregulated in AIS and reflects systemic inflammation.
- PK2 has limited predictive capacity for neurological functional recovery in AIS patients.
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