Age and Sex Moderate the Effects of Sleep Quality on Resting-State Functional Connectivity in the Salience and
Selene Tan1, Sepehr Gourabi2, Matthew R Cribbet1
1The University of Alabama.
Abstract:
Aging often coincides with declining sleep quality, which can contribute to cognitive decline and increased dementia risk. Neuroimaging offers valuable insights into how poor sleep may affect brain health before cognitive or behavioral changes appear. Given the different prevalence rates of dementia between sexes, sleep disturbances might uniquely impact females relative to males. The goal of this study was to investigate how age and sex moderate the impact of sleep quality on resting-state functional connectivity. Based on the extant literature, we predicted that sleep quality would significantly impact connectivity in the default mode network, salience network, and the amygdala. Adults (N = 95), aged 20-74, completed the Pittsburgh Sleep Quality Index and underwent two 5-min sessions of resting-state MRI. Three-way interactions between age, sex, and sleep quality were found between the default mode network and the left superior parietal lobule. A two-way interaction between age and sleep quality was found between the salience network and right precentral/postcentral gyrus. No relationships were found using the amygdala as a seed region. Furthermore, sleep consistently contributed to the sleep quality-connectivity effects found for young adults and multiple sleep components varied in older adults. The results suggest that poor sleep affects the salience networks in both males and females, with variations in adaptive patterns depending on age. The default mode network appears particularly sensitive to sleep impairments in females, consistent with early desegregation of brain networks and increased risk for dementia. The alterations in young adults support the hyperarousal hypothesis as a potential contributor to insomnia.
More Related Videos
09:01A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
Published on: May 7, 2014
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
Related Concept Videos
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Understanding Sleep
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Optimal Arousal Theory
Inverted U-Shaped Performance Curve
The...
Relationship Formation
