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Association Between Sleep and Functional Outcome in Critically Ill Patients
Rebecca Dutta1, Leslie C West2, Ajay Sampat3
1University of California Davis.
Research Square
|July 25, 2025
Summary
In critically ill patients, achieving sleep was linked to better clinical outcomes. Neurocritical patients slept more, and sleep presence improved functional outcomes, regardless of disease severity.
Area of Science:
- Neuroscience
- Critical Care Medicine
- Sleep Medicine
Background:
- Sleep disturbances are common in critically ill patients.
- The relationship between sleep and clinical outcomes in acute brain injury and critical illness requires further investigation.
Purpose of the Study:
- To examine the association between sleep and clinical outcomes in patients with acute brain injury and critical illness.
- To determine if sleep presence impacts functional outcomes in critically ill patients.
Main Methods:
- Retrospective analysis of 262 critically ill patients monitored with continuous electroencephalography (2018-2020).
- Clinical outcome assessed using the modified Rankin Scale (mRS).
- Statistical modeling controlled for anesthetic concentration, diagnosis, sex, and disease severity (APACHE score).
Main Results:
- Twenty-one percent of patients achieved sleep.
- Patients achieving sleep had significantly better outcomes (43%) compared to those without sleep (26%).
- Neurological patients achieved sleep more frequently (27%) than other diagnoses (14%).
Conclusions:
- Sleep presence in critically ill patients, particularly neurocritical patients, is associated with improved functional outcomes.
- Further research is needed to explore sleep augmentation and anesthetic effects on outcomes.
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