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Varied Characteristics of Recovered Patients with Biliary Atresia
Firyal Nadiah Rahmah1,2, Rendi Aji Prihaningtyas1,2, Bagus Setyoboedi1,2
1Department of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Insights
Early diagnosis and intervention are crucial for improving outcomes in infants with biliary atresia (BA). Younger age at diagnosis, shorter jaundice duration, and absence of portal hypertension significantly improve recovery rates in BA patients.
Area of Science:
- Pediatric Gastroenterology
- Hepatology
- Neonatal Cholangiopathies
Background:
- Biliary atresia (BA) is a severe infantile liver disease causing cholestasis and fibrosis.
- Untreated BA progresses to liver cirrhosis and failure.
- Early identification of prognostic factors is vital for treatment optimization.
Purpose of the Study:
- To evaluate demographic, clinical, and laboratory features of infants with BA.
- To identify prognostic indicators for treatment success in biliary atresia.
- To analyze factors influencing recovery and survival in pediatric BA patients.
Main Methods:
- Retrospective observational study of 152 infants diagnosed with BA.
- Analysis of clinical data, laboratory results, and treatment outcomes.
- Statistical assessment of factors impacting BA patient recovery and survival.
Main Results:
- Mean patient age was 13.9 weeks; jaundice onset at 3.3 weeks, lasting 10.7 weeks.
- Overall survival rate was 81.6%, with 48% treatment failure.
- Younger age at diagnosis, shorter jaundice duration, and no portal hypertension correlated with better recovery.
Conclusions:
- Early diagnosis and intervention significantly improve outcomes in biliary atresia.
- Prognostic factors like age at diagnosis and portal hypertension status are key.
- Further research needed to optimize treatment strategies for enhanced long-term survival in BA.
Background/Aims:
Biliary atresia (BA) is a progressive cholangiopathy of infancy that leads to cholestasis, bile duct fibrosis, and liver cirrhosis if untreated. This study aimed to evaluate the demographic, clinical, and laboratory characteristics of infants with BA and identify prognostic factors influencing treatment outcomes.
Methods:
A retrospective observational design was used, analyzing medical records of 152 infants diagnosed with BA over a three-year period. Data included clinical manifestations, laboratory findings, diagnostic procedures, and treatment outcomes. Statistical analyses were conducted to assess factors affecting recovery and survival.
Results:
The results indicated a mean patient age of 13.9 weeks, with jaundice onset at 3.3 weeks and an average duration of 10.7 weeks. The overall survival rate was 81.6%, while 48% experienced treatment failure. Recovery rates were significantly associated with younger age at diagnosis (p=0.000), shorter jaundice duration (p=0.002), and absence of portal hypertension (p<0.001).
Conclusions:
These findings highlight the importance of early diagnosis and intervention in improving BA outcomes. Future research should focus on optimizing treatment strategies to enhance long-term survival.
