Related Experiment Video

Updated: Sep 14, 2025

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.3K

Vaccination in paediatric, adolescent, and transitional-age rheumatic diseases: a systematic review

Takuma Ohnishi1,2, Hiroyuki Wakiguchi3,4, Shingo Ishimori5,6

  • 1Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

Modern Rheumatology
|July 25, 2025
PubMed

Insights

Vaccination is generally safe and effective for pediatric rheumatic diseases. Live vaccines may be cautiously used in some patients, but more research is needed, especially for newer treatments.

Area of Science:

  • Rheumatology
  • Immunology
  • Pediatrics

Background:

  • Rheumatic diseases affect children, adolescents, and young adults.
  • Vaccination is crucial for preventing infections in immunocompromised individuals.

Purpose of the Study:

  • To systematically review the efficacy and safety of vaccines in pediatric, adolescent, and transitional-age patients with rheumatic diseases.
  • To identify evidence gaps regarding vaccination in these populations.

Main Methods:

  • Systematic literature search of PubMed up to September 2022.
  • Inclusion of studies on various vaccines including diphtheria, pertussis, tetanus, pneumococcus, influenza, hepatitis A/B, HPV, poliovirus, MMR, varicella, and tuberculosis.

Main Results:

  • Non-live vaccines are generally immunogenic and safe for patients with rheumatic diseases.
  • Live attenuated vaccines are typically contraindicated in patients on immunosuppressants, but may be considered in specific cases with low-dose therapies.
  • Meta-analysis was not feasible due to heterogeneity in study designs and patient populations.

Conclusions:

  • Significant evidence gaps exist for vaccination in pediatric rheumatic diseases, particularly concerning newer therapies like biologics and Janus kinase inhibitors.
  • Further research is essential to guide vaccination strategies in this vulnerable population.
Abstract

Keywords:
Bacille Calmette–Guérindiphtheria, pertussis, and tetanus vaccinehepatitis A virus vaccinehepatitis B virus vaccinehuman papillomavirus vaccineinactivated polio vaccineinfluenza vaccinemeasles, mumps, and rubella vaccinepneumococcal vaccinevaricella zoster virus vaccine

More Related Videos

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

3.5K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

369

Related Concept Videos

Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
32
Vaccinations01:51

Vaccinations

Overview
45.3K
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
38
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
43
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
59
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.2K