Midline sinuses of the upper lip. Case report.
Scandinavian Journal of Plastic and Reconstructive Surgery
|January 1, 1985
Summary
Midline sinuses of the upper lip, rare congenital anomalies, are presented in three new cases. These findings suggest a link between upper lip sinuses and developmental disorders like Pierre Robin syndrome.
Area of Science:
- Craniofacial development
- Congenital anomalies
- Medical genetics
Background:
- Midline sinuses of the upper lip are rare congenital malformations.
- Previous literature describes nine such cases, typically extending from the columella to the frenulum.
Observation:
- Three new cases of midline upper lip sinuses are presented.
- Case 1: Sinus from philtrum to frenulum in a child with Pierre Robin syndrome.
- Case 2 & 3: Sinuses located in the frenulum, one in a patient with bilateral midline nasal sinuses, and another in a child with partial median cleft lip.
Findings:
- The midline sinus likely results from abnormal development of the nasofrontal process.
- The co-occurrence with Pierre Robin syndrome suggests a potential shared etiology.
Implications:
- These findings support the hypothesis that Pierre Robin syndrome may have developmental origins beyond fetal positioning.
- Further research into the genetic and developmental pathways of midline facial anomalies is warranted.
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