Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Significant bleeding at kidney resection after experimental denervation.

C M Kullendorff, E Zoucas

    Scandinavian Journal of Urology and Nephrology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Peripheral leucocyte count variations in rectal cancer treatment.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2009
    Same author

    Local infusion of the nitric oxide donor Sin-1 after angioplasty. Effects on intimal hyperplasia in porcine coronary arteries.

    Acta radiologica (Stockholm, Sweden : 1987)·2003
    Same author

    Differential roles of endogenous nitric oxide on neural regulation of basal exocrine pancreatic secretion in intact and denervated pancreas.

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2002
    Same author

    Stenting of the biliary tract in children.

    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie·2002
    Same author

    Effect of selective denervation of the rat pancreas on pancreatic endocrine function.

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes·2001
    Same author

    Cytogenetics of hepatoblastoma: further characterization of 1q rearrangements by fluorescence in situ hybridization: an international collaborative study.

    Medical and pediatric oncology·2000

    Microsurgical denervation of the kidney in rats significantly increased blood loss and bleeding time during kidney resection. This suggests interrupted renal nerve supply impacts hemostasis, with potential implications for human renal surgery.

    Area of Science:

    • Nephrology
    • Surgical Research
    • Physiology

    Background:

    • Renal denervation is a surgical procedure that involves severing the nerves connected to the kidney.
    • The impact of renal denervation on intraoperative bleeding and hemostasis during kidney surgery is not fully understood.

    Purpose of the Study:

    • To investigate the effects of microsurgical renal denervation on blood loss and bleeding parameters in a rat model undergoing kidney resection.
    • To determine if denervation influences platelet function and coagulation parameters.

    Main Methods:

    • Rats underwent microsurgical resection of renal nerves.
    • One week post-denervation, standardized kidney resections were performed.
    • Blood loss, bleeding time, hemoglobin, hematocrit, platelet count, and activated partial thromboplastin time (APTT) were measured.

    Related Experiment Videos

    Main Results:

    • Denervated rats exhibited significantly increased blood loss and prolonged bleeding time during kidney resection compared to controls.
    • Hemoglobin and hematocrit levels decreased significantly in denervated rats post-resection.
    • Platelet count, APTT, and platelet aggregation remained unaffected by renal denervation.

    Conclusions:

    • Microsurgical denervation of the kidney leads to increased bleeding during renal parenchymal resection in rats.
    • Interruption of renal nerve supply appears to impair hemostasis, suggesting a role for the renal nerves in controlling bleeding.
    • Findings may have significant implications for understanding and managing bleeding risks in human renal surgery.